“Electrical stimulation has been shown to accelerate wound healing and increase cutaneous perfusion in human studies. Electrical stimulation is an adjunctive therapy that is underutilized in plastic surgery and could improve flap and graft survival, accelerate postoperative recovery, and decrease necrosis following foot reconstruction.”
Thakral et al, Burns & Trauma Sept. 2013
”This study indicates that ES accelerates acute cutaneous wound healing evidenced by a reduction in wound volume, diameter and surface area and an increase in blood flow. There is clear evidence from invasive and non-invasive modalities that treatment with ES resulted in increased angiogenesis. This study further substantiates the role of ES in enhancing cutaneous wound repair evidenced by quantifiable objective measures and histological analysis observed in multiple time points.
Ud-din et al PLoS ONE 10(4) 2015
“New developments in accelerating wound healing can have immense beneficial socioeconomic impact. Electrostimulation therapy of wounds has shown to be a promising treatment option with no- device-related adverse effects. Rapid clinical translation of the evolving understanding of bio-molecular mechanisms underlying the effects of electrical simulation on wound healing would positively impact upon enhancing patient’s QOL.
Hunkler, Journal of Multidisciplinary Healthcare, 20 April 2017
“Electric fields activate multiple cellular signaling pathways such as PI3K/PTEN, the membrane channel of KCNJ15/Kir4.2 and intracellular polyamines. These pathways are involved in the sensing of physiological electric fields, directional cell migration (galvanotaxis, also known as electrotaxis), and possibly other cellular responses. Importantly, electric fields provide a dominant and over-riding signal that directs cell migration. Electrical stimulation could be a promising therapeutic method in promoting wound healing and activating regeneration of chronic and non-healing wounds.”
Tai et al. Burns & Trauma (2018)